CASP8
caspase 8, apoptosis-related cysteine peptidase
Sinónimos:
ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Especie:
Human CASP8 (841), Mouse Casp8 (12370), Rat Casp8 (64044), domestic guinea pig Casp8 (100713334), naked mole-rat Casp8 (101702773), sheep CASP8 (101107334), Zebrafish casp8 (58022), domestic cat CASP8 (100142684), cow CASP8 (507481), Horse CASP8 (100066502) ...Más
ID UniProtKB:
ID del gen:
- Human(841) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
- Mouse(12370) caspase 8
- Rat(64044) caspase 8
- domestic guinea pig(100713334) caspase 8, apoptosis-related cysteine peptidase
- naked mole-rat(101702773) caspase 8, apoptosis-related cysteine peptidase
- sheep(101107334) caspase 8, apoptosis-related cysteine peptidase
- Zebrafish(58022) caspase 8, apoptosis-related cysteine peptidase
- domestic cat(100142684) caspase 8, apoptosis-related cysteine peptidase
- cow(507481) caspase 8, apoptosis-related cysteine peptidase
- Horse(100066502) caspase 8, apoptosis-related cysteine peptidase
- dog(488473) caspase 8, apoptosis-related cysteine peptidase
- chicken(395284) caspase 8, apoptosis-related cysteine peptidase
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1, clone 2B12.1, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
western blot
western blot
Anti-Caspase-8 Antibody, clone C15, ,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot
western blot
Anti-Caspase-8 Antibody, clone 3B10, clone 3B10, from rat,
Reactividad de especies
mouse
Aplicación
flow cytometry
western blot
western blot
Anti-Cleaved Caspase 8 Rabbit Monoclonal Antibody, clone RM442, affinity purified immunoglobulin,
Reactividad de especies
human
Aplicación
Anti-Cleaved Caspase-8 Antibody, clone 1K3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Referencia del producto
Descripción
Especie
Caspase 8 human, ≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine tagged), buffered aqueous solution, ≥1,000 units/mg protein,
Especie
human
esiRNA
Small Molecule - Substrate
Referencia del producto
Descripción
Especie
N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin, ≥97% (HPLC), powder,
Especie
rat, mouse, human