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42597

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3′-脱氧胸苷 5′-三磷酸 钠盐 溶液

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

同義詞:

2′,3′-二脱氧胸苷 5′-三磷酸, ddTTP

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About This Item

經驗公式(希爾表示法):
C10H16N2NaO13P3
CAS號碼:
分子量::
488.15
MDL號碼:
分類程式碼代碼:
41116105
PubChem物質ID:

產品線

BioChemika

等級

puriss. p.a.

化驗

≥98.0% (HPLC)

濃度

10.0-11.0 mmol/L (UV)

技術

MALDI-MS: suitable

雜質

≤1.5% ddNDP (HPLC)

適合性

corresponds for UV test

儲存溫度

−20°C

SMILES 字串

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

InChI 密鑰

QJSZKDPCBDXBCK-KZYPOYLOSA-M

一般說明

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

包裝

packaging : 1 μmol (approx. 91-100 μL)

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Elena N Ilina et al.
Frontiers in microbiology, 4, 186-186 (2013-07-13)
Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.
Sylvia Steininger et al.
Nucleic acids research, 38(6), 1853-1865 (2009-12-31)
The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We
Konstantin Akopiants et al.
Nucleic acids research, 42(5), 3125-3137 (2013-12-29)
To track the processing of damaged DNA double-strand break (DSB) ends in vivo, a method was devised for quantitative measurement of 3'-phosphoglycolate (PG) termini on DSBs induced by the non-protein chromophore of neocarzinostatin (NCS-C) in the human Alu repeat. Following
Jess Tyson et al.
BMC genomics, 10, 453-453 (2009-09-30)
Copy number variation (CNV) in the human genome is recognised as a widespread and important source of human genetic variation. Now the challenge is to screen for these CNVs at high resolution in a reliable, accurate and cost-effective way. Multiplex
E Matthes et al.
Biochemical and biophysical research communications, 148(1), 78-85 (1987-10-14)
The sugar-modified dTTP analogues 2',3'-didehydro-2',3'-dideoxy-thymidine 5'-triphosphate (ddeTTP), 2',3'-dideoxythymidine 5'-triphosphate (ddTTP), 3'-fluorothymidine 5'-triphosphate (FdTTP), and 3'-azidothymidine 5'-triphosphate (N3dTTP) are demonstrated to be very effective and selective inhibitors of the HIV-associated reverse transcriptase (HIV-RT). This conclusion is based on a comparison of

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