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α-氰基-4-羟基肉桂酸

matrix substance for MALDI-MS, ≥99.0% (HPLC)

同義詞:

α-CCA, α-CHCA, α-氰基, 4-HCCA, ACCA

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About This Item

線性公式:
HOC6H4CH=C(CN)CO2H
CAS號碼:
分子量::
189.17
Beilstein:
3271427
EC號碼:
MDL號碼:
分類程式碼代碼:
12000000
PubChem物質ID:
NACRES:
NA.21

等級

matrix substance for MALDI-MS

品質等級

化驗

≥99.0% (HPLC)

形狀

solid

分析物化學類別

glycans, peptides, proteins

技術

MALDI-MS: suitable

mp

245-250 °C (lit.)
245-250 °C

溶解度

methanol: 10 mg/mL, clear

正離子痕跡

Ba: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
K: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤10 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

吸收

≥2000 at 337 nm (mol. absorption)

SMILES 字串

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI 密鑰

AFVLVVWMAFSXCK-VMPITWQZSA-N

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一般說明

α-氰基-4-羟基肉桂酸(α-CHCA)广泛用作基质,以促进基质辅助激光解吸/电离(MALDI)飞行时间(TOF)质谱仪中肽和蛋白的电离。

應用

α-CHCA用作改善MALDI-TOF上低浓度蛋白消化物检测的基质。

其他說明

在蛋白组学中 用于 MALDI-MS(基质辅助激光解吸电离质谱)肽分析的基质物质

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產品號碼
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訂價

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Skin Sens. 1B

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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S.D. Patterson, V. Katta
Analytical Chemistry, 66, 3729-3729 (1994)
J Gobom et al.
Analytical chemistry, 73(3), 434-438 (2001-02-24)
We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of
Xiangping Zhu et al.
Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
Alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) as a matrix facilitates the ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. The matrix itself also ionizes and so do its sodium and potassium adducts. Matrix clusters and metal
Martin Winter et al.
SLAS discovery : advancing life sciences R & D, 24(7), 766-777 (2019-05-07)
Microbial-dependent trimethylamine (TMA) generation from dietary precursors such as choline was recently linked to cardiovascular diseases (CVDs) as well as chronic kidney disease (CKD). Inhibition of TMA-generating enzymes in gut bacteria would be an innovative approach to treat these diseases.
Kevser Biberoglu et al.
Biochimica et biophysica acta, 1834(4), 745-753 (2013-01-29)
Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was to determine whether soluble tetrameric AChE includes

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