5.08015

CTOP

• 同義詞: CTOP, µ Opioid Receptor Antagonist, CTOP
• 經驗公式（希爾表示法）: C₅₀H₆₇N₁₁O₁₁S₂
• CAS號碼: 103429-31-8
• 分子量：: 1062.26
• MDL號碼: MFCD00076708
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥95% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 0.96 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: water: soluble
• 儲存溫度: −20°C
• SMILES 字串: S1SCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1(C)C)C(=O)NC(C(O)C)C(=O)N)C(O)C)CCCN)Cc4c5c([nH]c4)cccc5)Cc3ccc(cc3)O)NC(=O)C(N)Cc2ccccc2
• InChI: 1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
• InChI 密鑰: PZWWYAHWHHNCHO-UHFFFAOYSA-N

描述

一般說明

A potent antagonist highly selective for µ opioid receptor (K_i = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.

生化／生理作用

Primary Target
mu opioid

警告

Toxicity: Standard Handling (A)

序列

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)

外觀

Supplied as trifluoracetate salt

其他說明

Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable