SML1347

爱维莫潘

≥98% (HPLC)

• 同義詞: ADL-8-2698, LY-246736, N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine
• 經驗公式（希爾表示法）: C₂₅H₃₂N₂O₄
• CAS號碼: 156053-89-3
• 分子量：: 424.53
• MDL號碼: MFCD09838268
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825803
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D +46 to +52°, c = 1.0 in DMSO
• 顏色: white to beige
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)CC2=CC=CC=C2)CC[C@]1(C3=CC=CC(O)=C3)C
• InChI: 1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
• InChI 密鑰: UPNUIXSCZBYVBB-JVFUWBCBSA-N
• 基因資訊: human ... OPRM1(4988)

描述

生化／生理作用

Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist.

Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist. As a drug, Alvimopan is given to patients undergoing bowel surgery to protect the bowel from the effects of opioid medications that are used to treat pain, blocking the undesirable GI side-effects of the opioid agonists without affecting analgesia or causing withdrawal. Alvimopan does not cross the blood-brain barrier, competitively binding to gastrointestinal tract mu-opioid receptors.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H315,H319,H400
• 防範說明: P273 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable