5.06271

Ketanserin Tartrate

• 同義詞: Ketanserin Tartrate, 5-HT _2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
• 經驗公式（希爾表示法）: C₂₂H₂₂FN₃O₃ · xC₄H₆O₆
• CAS號碼: 83846-83-7
• 分子量：: 395.43 (free base basis)
• MDL號碼: MFCD00084651
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥97% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 1.49 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: soluble
• 儲存溫度: 2-8°C
• SMILES 字串: Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4c(cccc4)C3=O.OC(C(O)C(=O)O)C(=O)O.O
• InChI: 1S/C22H22FN3O3.C4H6O6.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10;/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10);1H2
• InChI 密鑰: KJJRKCWDAHTVRL-UHFFFAOYSA-N

描述

一般說明

A selective 5-HT_2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT_2AR (K_i = 1.49 nM) relative to other family members like 5-HT_2BR (K_i = 740 nM) and 5-HT_2CR (K_i = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT_2AR and 5-HT_2CR activity.

生化／生理作用

Primary Target
5-HT_2A

警告

Toxicity: Toxic (F)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.
Leysen, J. E. et al. 1981. Life Sci.28, 1015.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable