B8312

BNTX maleate salt hydrate

≥98% (HPLC)

• 同義詞: 7(E)-Benzylidenenaltrexone maleate salt hydrate, BNTX-7 maleate salt hydrate, Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-,(5a,7E)- maleate salt hydrate
• 經驗公式（希爾表示法）: C₃₁H₃₁NO₈ · xH₂O
• 分子量：: 545.58 (anhydrous basis)
• MDL號碼: MFCD12912399
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329773306
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: yellow
• 溶解度: DMSO: >20 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: O.OC(=O)\C=C/C(O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)\C(C[C@@]35O)=C\c6ccccc6)CC7CC7
• InChI: 1S/C27H27NO4.C4H4O4.H2O/c29-20-9-8-18-13-21-27(31)14-19(12-16-4-2-1-3-5-16)23(30)25-26(27,22(18)24(20)32-25)10-11-28(21)15-17-6-7-17;5-3(6)1-2-4(7)8;/h1-5,8-9,12,17,21,25,29,31H,6-7,10-11,13-15H2;1-2H,(H,5,6)(H,7,8);1H2/b19-12+;2-1-;/t21-,25+,26+,27-;;/m1../s1
• InChI 密鑰: AGUNLJBLOJAUKM-ZKJXOIBSSA-N

描述

應用

BNTX, a selective nonpeptide σ1 opioid receptor (DOR1) antagonist, is used in σ opioid receptor research to help differentiate and characterized the function and role of the σ1 opioid receptor versus other σ opioid receptor subtypes. BNTX was used to help define the role of σ1 opioid receptors in neurological processes such as anxiety. It was used to help define the role of σ opioid receptors in myocardial infarct development and size.

生化／生理作用

BNTX is a selective d1 non peptide opioid receptor antagonist.

BNTX is a selective nonpeptide δ₁ opioid receptor antagonist. It antagonizes the effect of D-Pen^2,5-enkephalin (a δ₁ agonist 4-6 fold, but did not affect the activity of δ₂ or μ agonists.<<<107>>> BNTX is used to discriminate among opioid receptor subtypes in effects such as alcohol and drug dependence. It binds 100× more tightly to δ₁ than to δ₂ receptors. In the tail-flick assay, antinocieceptive ED50 = 646.4 pmol/mouse.

特點和優勢

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H319,H400
• 防範說明: P273 - P305 + P351 + P338
• 危險分類: Aquatic Acute 1 - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves