N7758

纳洛酮盐酸盐二水合物 盐酸盐 二水合物

≥98% (TLC and titration), powder

• 經驗公式（希爾表示法）: C₁₉H₂₁NO₄ · HCl · 2H₂O
• CAS號碼: 51481-60-8
• 分子量：: 399.87
• Beilstein: 6260807
• MDL號碼: MFCD00150901
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278050
• NACRES: NA.77

屬性

• 化驗: ≥98% (TLC and titration)
• 形狀: powder
• 光學活性: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• 顏色: white to off-white
• 溶解度: ethanol: 3.3 mg/mL; H₂O: 50 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
• InChI 密鑰: TXMZWEASFRBVKY-IOQDSZRYSA-N
• 基因資訊: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

描述

應用

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

生化／生理作用

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

特點和優勢

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

光敏。

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves