推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
yellow-orange
溶解度
DMSO: 15 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChI 密鑰
ACPOUJIDANTYHO-UHFFFAOYSA-N
一般說明
一种有效的，细胞可渗透的，选择性并可逆的c-Jun N末端激酶（JNK）抑制剂（JNK-1和JNK-2的IC50 = 40 nM，JNK-3的IC50=90 nM）。这种抑制对于ATP具有竞争性。与ERK1和p38-2 MAP激酶相比，对JNK的选择性高300倍以上。抑制c-Jun的磷酸化，阻断IL-2、IFN-γ、TNF-α、COX-2的细胞表达。阻断IL-1诱导的磷酸化-Jun积累和c-Jun转录的诱导。也可使用50 mM（5 mg/454 µl）JNK抑制剂II（目录号420128）的DMSO溶液。
一种有效的，细胞可渗透的，选择性并可逆的c-Jun N末端激酶（JNK）抑制剂（JNK-1和JNK-2的IC50 = 40 nM，JNK-3的IC50=90 nM）。这种抑制对于ATP具有竞争性。与ERK1和p38-2 MAP激酶相比，对JNK的选择性高300倍以上。抑制c-Jun的磷酸化，阻断IL-2、IFN-γ、TNF-α、COX-2的细胞表达。阻断IL-1诱导的磷酸化-Jun积累和c-Jun转录的诱导。
生化／生理作用
主要靶标
JNK 1，JNK 2，JNK 3
JNK 1，JNK 2，JNK 3
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：40 nM，对于JNK-1和JNK-2；90 nM，对于JNK-3
包裝
用惰性气体包装
警告
毒性：标准处理（A）
準備報告
对于每10 µM浓度的JNK抑制剂II，在培养基中应包含0.1%DMSO。培养基的预热和向培养基中添加BSA可能会增强其溶解度。
重構
复溶后，等分并在-20°C下冷冻保存。储备溶液在-20°C下可稳定保存2个月。
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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