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Key Documents

559389

Sigma-Aldrich

SB 203580

≥98% (HPLC), film (Thin), p38 MAP kinase inhibitor, Calbiochem®

同義詞:

SB 203580, 4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)1H-咪唑,p38 MAP激酶抑制剂XVI

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About This Item

經驗公式(希爾表示法):
C21H16FN3OS
CAS號碼:
分子量::
377.43
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

SB 203580, SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

品質等級

化驗

≥98% (HPLC)

形狀

film (Thin)

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

溶解度

DMSO: 30 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChI 密鑰

CDMGBJANTYXAIV-UHFFFAOYSA-N

一般說明

降低表阿霉素诱导的细胞损伤和caspase-3/7活性。p38 MAP激酶的一种高度特异性、有效性、细胞渗透性、选择性、可逆性和ATP竞争性抑制剂(体外IC50=34 nM,细胞内为600 nM)。在100 µM时不会显著抑制JNK和p42 MAP激酶。抑制LPS刺激的人单核细胞和人单核细胞系THP-1产生IL-1和TNFα(IC50=50-100 nM)。抑制骨形态发生蛋白-2诱导的PC12细胞突起生长。还可抑制由胶原蛋白(IC50 = 0.2-1.0 µM)或血栓素类似物U-46619(目录号538944)引起的血小板聚集。也可提供SB 203580(目录号559398)在无水DMSO中的1 mg/ml溶液。
降低表阿霉素诱导的细胞损伤和caspase-3/7活性。p38激酶的一种高度特异性、有效性、细胞渗透性、选择性、可逆性和ATP竞争性抑制剂(体外IC50=34 nM,细胞内为600 nM)。也称为再激活激酶(RK)和CSBP(细胞因子合成抗炎药物结合蛋白)。即使在100 µM时也不会显著抑制JNK或p42 MAP激酶。抑制LPS刺激的人单核细胞和人单核细胞系THP-1产生IL-1和TNFα(IC50=50-100 nM)。SB203580也被证明是小鼠和大鼠体内炎症细胞因子产生的有效抑制剂。

生化/生理作用

产物与ATP竞争。
可逆性:是
细胞可渗透性:是
靶标IC50:在体外对p38 MAP激酶为34 nM,在细胞中为600 nM;对LPS刺激的人单核细胞和人单核细胞系TNF-α产生的IL-1和TNF-为50-100 nM;对胶原蛋白引起的血小板聚集为0.2-1.0 µM

警告

毒性:刺激性(B)

其他說明

Yamada.T., et al. 2012.Free Radic.Biol. Med. (In press)
Powell, D.J., et al. 2003.Mol.Cell Biol.23, 7794.
Davies, S.P., et al. 2000.Biochem.J.351, 95.
Iwasaki, S., et al. 1999.J. Biol. Chem.274, 26503.
Gallagher, T.F., et al. 1997.Bioorg.Med. Chem. 5, 49.
LoGrasso, P.V., et al. 1997.Biochem.36, 10422.
Hazzalin, C.A., et al. 1996.Curr.Biol.6, 1028.
Kramer, R.M., et al. 1996.J. Biol. Chem.271, 27723.
Saklatvala, J., et al. 1996.J. Biol. Chem. 271, 6586.
Cuenda, A., et al. 1995.FEBS Lett.364, 229.
Gallagher, T.F., et al. 1995.Bioorg.Med. Chem. Lett.5, 1171.
Lee, J.C., et al. 1994.Nature 372, 739.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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