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重要文件

860498P

Avanti

鞘氨醇 (d18:0)

Avanti Research - A Croda Brand

同義詞:

D-赤-鞘氨醇

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About This Item

經驗公式(希爾表示法):
C18H39NO2
CAS號碼:
分子量::
301.51
MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 10 mg (860498P-10mg)
pkg of 1 × 100 mg (860498P-100mg)
pkg of 1 × 25 mg (860498P-25mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1

InChI 密鑰

OTKJDMGTUTTYMP-ZWKOTPCHSA-N

一般說明

鞘氨醇(d18:0)是神经酰胺去饱和酶的底物。它是由于补充的甘氨酸向丝氨酸的相互转化而间接合成的。鞘氨醇(d18:0)分解代谢为神经酰胺。

應用

鞘氨醇(d18:0)已用于:
  • 作为标准品,利用液相色谱-串联质谱法定量表皮神经酰胺
  • 作为培养基补充,检测其对酵母细胞生长的效应
  • 制备牛血清白蛋白脂质复合物,研究其对非溶酶体-葡萄糖基神经酰胺酶β2(GBA2)抑制作用的效应

生化/生理作用

鞘氨醇(d18:0)的水平在1型遗传性感觉神经病细胞中没有改变。在肿瘤缺氧中观察到d18:0的积累。它可用作研究微生物多样性的生物标记物。

包裝

5 mL棕色玻璃螺旋盖小瓶(860498P-100mg)
5 mL棕色玻璃螺旋盖小瓶(860498P-10mg)
5 mL棕色玻璃螺旋盖小瓶(860498P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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存取文件庫

Altered sphingolipid metabolism induced by tumor hypoxia-new vistas in glycolipid tumor markers
Yin J, et al.
Febs Letters, 584(9), 1872-1878 (2010)
Sunyoung Hwang et al.
Cell reports, 29(8), 2473-2488 (2019-11-21)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease
Schonauer S, et al.
Test, 292(15), 6177-6189 (2017)
Tingting Qin et al.
Nucleic acids research, 42(18), e138-e138 (2014-07-27)
To enhance our knowledge regarding biological pathway regulation, we took an integrated approach, using the biomedical literature, ontologies, network analyses and experimental investigation to infer novel genes that could modulate biological pathways. We first constructed a novel gene network via

Global Trade Item Number

庫存單位GTIN
860498P-10MG4061835317387
860498P-100MG4061835317370
860498P-25MG4061835317394

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