反應適用性
reaction type: click chemistry
reagent type: chemical modification reagent
reagent type: fluorescent-labelling reagent
品質等級
儲存溫度
−20°C
應用
TAMRA-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more hydrophilic and reactive than standard TCOs. The fluorescent TAMRA-a-TCO was developed for rapid, live-cell and in vivo experiments. It is cell permeable, reacts with tetrazines intracellularly via Diels-Alder chemistry, and exhibits reduced background fluorescence relative to other TAMRA TCO tags when imaged using fluorescence microscopy (illumination at λ=531 nm).
Other new a-TCOs:
Other new a-TCOs:
- NHS ester-a-TCO (MKE211512)
- Alkyne-a-TCO (MKE211515)
- Amine-a-TCO (MKE211516)
相關產品
產品號碼
描述
訂價
儲存類別代碼
11 - Combustible Solids
Angewandte Chemie (International ed. in English), 60(27), 14975-14980 (2021-03-21)
trans-Cyclooctenes (TCOs) are essential partners in the fastest known bioorthogonal reactions, but current synthetic methods are limited by poor diastereoselectivity. Especially hard to access are hydrophilic TCOs with favorable physicochemical properties for live cell or in vivo experiments. Described is a
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