919950

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine

>98%

• 同義詞: b-Tz, Minimal tetrazine
• 經驗公式（希爾表示法）: C₁₆H₁₄N₄S
• CAS號碼: 2378619-75-9
• 分子量：: 294.37
• MDL號碼: MFCD33021752
• 分類程式碼代碼: 12352106
• NACRES: NA.22

屬性

• 品質等級: 100
• 化驗: >98%
• 形狀: powder
• 反應適用性: reaction type: click chemistry
• SMILES 字串: S(Cc2ccc(cc2)c3ccccc3)c1nnc(nn1)C
• InChI 密鑰: YATUIOCNNCZRCH-UHFFFAOYSA-N

描述

應用

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine (b-Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications. Tetrazines are often incorporated into chemical probes or other small-molecule tools using linkers that may impact physicochemical properties or the performance of the resulting conjugate product. Here, Lambert et al demonstrated the linker-free incorporation of b-Tz via silver-mediated Liebeskind-Srogl cross-coupling with a variety of aryl and heteroaryl boronic acids. This ″minimal″ tetrazine approach will facilitate the introduction of tetrazine into diverse complex molecules and improved probes for live-cell imaging and in vivo chemistry.

Supporting products
PdCl₂(dppf): 697230
Ag₂O: 226831

其他說明

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable