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Key Documents

275875

Sigma-Aldrich

4-氨基吡啶

≥99%

同義詞:

4-吡啶胺, 4AP, 对氨基吡啶, 氨吡啶

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About This Item

經驗公式(希爾表示法):
C5H6N2
CAS號碼:
分子量::
94.11
Beilstein:
105782
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

≥99%

形狀

solid

bp

273 °C (lit.)

mp

155-158 °C (lit.)

溶解度

DMF: soluble(lit.)
DMSO: soluble(lit.)
THF: soluble(lit.)
acetone: soluble(lit.)
acetonitrile: soluble(lit.)
ethanol: soluble(lit.)
isopropanol: soluble(lit.)
methanol: soluble(lit.)
water: soluble(lit.)

SMILES 字串

Nc1ccncc1

InChI

1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChI 密鑰

NUKYPUAOHBNCPY-UHFFFAOYSA-N

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一般說明

4-氨基吡啶(4-AP)可阻断其他神经膜中的电压依赖型钾离子通道。4-AP是一种K+通道阻断剂,在体外实验中可引起癫痫样放电,并且是动物和人的强效惊厥剂

應用

4-氨基吡啶可用作:
  • 制备药理学上极为重要的4-氨基-N吡啶-4-乙基-丁酰胺盐酸盐的反应剂。
  • 制备肉桂酸衍生物作为强效胆碱酶抑制剂的反应剂。
  • 制备batracylin氮杂类似物——拓扑异构酶II抑制剂的起始物料。

訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

312.8 °F

閃點(°C)

156 °C

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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S Yamaguchi et al.
Epilepsy research, 11(1), 9-16 (1992-03-01)
The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and
Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer′s disease
Lan J-S, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 776-788 (2017)
H Bostock et al.
The Journal of physiology, 313, 301-315 (1981-01-01)
1. 4-Aminopyridine (4AP) and tetraethylammonium ions (TEA), which block voltage-dependent potassium channels in other nerve membranes, have been used to study nerve conduction in fibres of normal rat spinal roots and those demyelinated with diphtheria toxin. The pharmacological actions have
M B Gill et al.
British journal of pharmacology, 160(6), 1417-1429 (2010-07-02)
A new class of heterotricyclic glutamate analogues recently was generated by incorporating structural elements of two excitotoxic marine compounds, kainic acid and neodysiherbaine A. Rather than acting as convulsants, several of these 'IKM' compounds markedly depressed CNS activity in mice.
Silvia Ghirga et al.
Journal of the Optical Society of America. A, Optics, image science, and vision, 37(4), 643-652 (2020-05-14)
It has been recently demonstrated that the exposure of naive neuronal cells to light-at the basis of optogenetic techniques and calcium imaging measurements-may alter neuronal firing. Indeed, understanding the effect of light on nongenetically modified neurons is crucial for a

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