KCNA1

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Synonyms:

AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1

Species:

Human KCNA1 (3736), Mouse Kcna1 (16485), Rat Kcna1 (24520), Domestic Rabbit KCNA1 (100037722), Domestic Rabbit KCNA1 (100037717), domestic guinea pig Kcna1 (100731979), Zebrafish kcna1 (327087), cow KCNA1 (538703), Horse KCNA1 (100051648), domestic cat KCNA1 (101093364) ...More

UniProtKB ID:

Q09470, A6NM83, Q3MIQ9

Gene ID:

Human(3736) Summary: This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
Mouse(16485) potassium voltage-gated channel, shaker-related subfamily, member 1
Rat(24520) potassium voltage-gated channel, shaker-related subfamily, member 1
Domestic Rabbit(100037722) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Domestic Rabbit(100037717) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
domestic guinea pig(100731979) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Zebrafish(327087) potassium voltage-gated channel, shaker-related subfamily, member 1
cow(538703) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Horse(100051648) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
domestic cat(101093364) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
dog(486732) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chicken(428101) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Products (22)
Peer Reviewed Papers (72)

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