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Merck

V3639

Sigma-Aldrich

缬氨霉素

Ready Made Solution, ~1 mg/mL in DMSO

别名:

Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

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About This Item

经验公式(希尔记法):
C54H90N6O18
CAS号:
分子量:
1111.32
Beilstein:
78657
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.76

生物源

Streptomyces sp.

品質等級

化驗

≥90% (HPLC)

形狀

liquid

儲存條件

(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)

濃度

~1 mg/mL in DMSO

顏色

colorless

抗生素活性譜

Gram-positive bacteria
parasites
viruses

作用方式

cell membrane | interferes

運輸包裝

wet ice

儲存溫度

2-8°C

SMILES 字串

CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

InChI

1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1

InChI 密鑰

FCFNRCROJUBPLU-RPUZOQEISA-N

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一般說明

化学结构:肽

應用

缬氨霉素是具有钾离子性质的环状十二肽。 它用于研究生物系统中的离子运输。 用于研究其对完整细胞及细菌、酵母菌生长的抑制作用。 用于诱导细胞凋亡

生化/生理作用

K+选择性离子载体环羧酚酸肽;钾离子载体,其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。
K+选择性离子载体,其可解耦氧化磷酸化作用。
缬氨霉素是一种K+-选择性离子载体环缩肽。 它是一种钾离子载体,其可解偶联氧化磷酸化,诱导鼠胸腺细胞凋亡,抑制NGF诱导的神经元分化,并拮抗ET诱导的血管收缩。 据报道它具有杀虫、杀线虫和抗病毒作用

其他說明

保存于密闭容器内,置于干燥通风处。吸湿的。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

188.6 °F - closed cup

閃點(°C)

87 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Seizures can occur spontaneously and in a recurrent manner, which defines epilepsy; or they can be induced in a normal brain under a variety of conditions in most neuronal networks and species from flies to humans. Such universality raises the
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