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Merck

N7143

Sigma-Aldrich

尼日利亚菌素 钠盐

≥98% (TLC)

别名:

Helexin C, 抗生素K178, 抗生素X464, 聚醚A, 阿扎霉素M

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About This Item

经验公式(希尔记法):
C40H67NaO11
CAS号:
分子量:
746.94
Beilstein:
3892398
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

Streptomyces hygroscopicus

品質等級

化驗

≥98% (TLC)

形狀

powder

抗生素活性譜

Gram-positive bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

[Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1

InChI 密鑰

MOYOTUKECQMGHE-PDEFJWSRSA-M

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一般說明

化学结构:聚醚
尼日利亚菌素是一种聚醚类离子载体,可用作跨线粒体膜的离子载体。它催化K+和H+的整体电中性交换(1),并用作钾离子外排的激活剂。 可经由不依赖炎性小体的NLRP3蛋白(NOD-, LRR- and pyrin domain-containing protein 3)特异性机制增强杀菌作用。尼日利亚菌素是由多个氧杂环和一个羟基组成的线性分子。在膜中连接成环,形成类似缬氨霉素的结构。尼日利亚菌素因失去一个质子而与阳离子结合后形成中性复合物,成为跨膜扩散的移动载体。尼日利亚菌素的质子化非复合物形式同样具有移动性。

應用

尼日利亚菌素钠盐已用于引起人巨噬细胞中的NLRP3炎性小体活化。还作为细菌毒素激发单核细胞分泌IL-1β。

生化/生理作用

破坏膜电位并刺激线粒体中 ATPase 活性的聚醚离子载体。离子选择性为 K+> Rb+≥ Cs+>> Na+

其他說明

作为离子选择电极 - 一种高效的 K+ 载体。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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