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Merck

P8813

Sigma-Aldrich

普罗替林 盐酸盐

≥99% (TLC), powder

别名:

N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride

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About This Item

经验公式(希尔记法):
C19H21N · HCl
CAS号:
分子量:
299.84
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥99% (TLC)

形狀

powder

顏色

white to off-white

溶解度

H2O: 50 mg/mL

SMILES 字串

Cl[H].CNCCCC1c2ccccc2C=Cc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

InChI 密鑰

OGQDIIKRQRZXJH-UHFFFAOYSA-N

基因資訊

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生化/生理作用

Norepinephrine uptake blocker.

特點和優勢

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

Shelf-life of the powder is at least three years at room temperature.

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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M M Makhay et al.
Pharmacology, biochemistry, and behavior, 63(2), 319-324 (1999-06-17)
The ability of indirectly acting agonists such as norepinephrine uptake inhibitors, serotonin reuptake inhibitors, and atypical antidepressants to substitute for clenbuterol, a beta-2 adrenergic agonist, was examined in rats trained to discriminate 0.03 mg/kg clenbuterol and saline using a fixed-ratio
F Sériès et al.
Chest, 104(1), 14-18 (1993-07-01)
We evaluated the effects of protriptyline on snoring characteristics in 14 nonapneic snorers (age range, 23 to 54 years; body mass index, 27.4 +/- 0.9 kg/m2, mean +/- SEM). The study design was a double-blind placebo-controlled crossover trial. Patients were
Sigrid C Veasey et al.
Sleep, 29(8), 1036-1044 (2006-09-02)
A significant number of patients with obstructive sleep apnea neither tolerate positive airway pressure (PAP) therapy nor achieve successful outcomes from either upper airway surgeries or use of an oral appliance. The purpose of this paper, therefore, was to systematically
K E Kinnamon et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 216(3), 424-428 (1997-12-24)
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective
Y Huang
British journal of pharmacology, 117(3), 533-539 (1996-02-01)
1 The effects of noradrenaline (NA) uptake inhibitors on contractions induced by NA, high K+, and 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat isolated aorta were investigated. 2 Protriptyline (0.3 microM) and amitriptyline (0.3 microM) produced an approximately parallel shift to the right

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