P6004

泼尼松龙

≥99% (HPLC), powder, glucocorticoid

• 别名: 1,4-孕甾二烯-11β,17α,21-三醇-3,20-二酮, 1-去氢氢化可的松, 1-去氢皮质醇, 11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮
• 经验公式（希尔记法）: C₂₁H₂₈O₅
• CAS号: 50-24-8
• 分子量: 360.44
• Beilstein: 1354103
• EC號碼: 200-021-7
• MDL號碼: MFCD00003649
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24898725
• NACRES: NA.77

属性

• product name: 泼尼松龙, ≥99%
• 生物源: synthetic (organic)
• 無菌: non-sterile
• 化驗: ≥99%
• 形狀: powder
• mp: 240 °C (dec.) (lit.)
• 溶解度: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• 起源: Johnson & Johnson
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI 密鑰: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• 基因資訊: human ... AR(367) , ESR1(2099) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Nr3c1(14815) ; rat ... Ar(24208)

说明

一般說明

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

應用

Prednisolone has been used for the Δ¹-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

生化／生理作用

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

特點和優勢

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

分析報告

Actual content given on label

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360FD
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves