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品質等級
化驗
≥95% (HPLC)
形狀
powder
技術
HPLC: suitable
顏色
white to off-white
儲存溫度
−20°C
SMILES 字串
CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
InChI
1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
InChI 密鑰
QHUYPZVMEJLSEB-UHFFFAOYSA-N
一般說明
羟基硫胺素是一种硫胺素抗代谢物，其饮食来源是通过摄入富含硫胺素的酸性食品。
應用
羟基硫胺素盐酸盐适用于：
- 作为参考标准品用于生成液相色谱-串联质谱（LC-MS/MS）的校准曲线定量测定红细胞中的羟基硫胺素焦磷酸盐 (OTPP)
- 作为人乳腺上皮细胞 (HMEC) 和乳腺癌细胞系中的硫胺素运输抑制剂
- 合成羟基硫胺素H苦酮酸盐
生化／生理作用
羟乙胺抑制转酮醇酶，即控制戊糖磷酸途径非氧化分支的酶。
羟基硫胺素（OT）是一种硫胺素拮抗剂。它是一种转酮醇酶抑制剂，用于研究抗转移机制，尤其是涉及金属蛋白酶（MMP）的机制。它可以显著提高人肝癌细胞（HCC）对索拉非尼的敏感性，从而有利于肿瘤抑制。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Emerging role of the pentose phosphate pathway in hepatocellular carcinoma
Kowalik MA, et al.
Frontiers in Oncology, 7, 87-87 (2017)
Novel structural aspects of oxythiamine, an antagonist of thiamine. Crystal structures of three salts,(oxythiamineH)(picrolonate) 2textperiodcentered
Hu NH, et al.
Inorgorganica Chimica Acta, 295(1), 71-83 (1999)
Thiamine and selected thiamine antivitamins?biological activity and methods of synthesis
Tylicki A, et al.
Bioscience Reports, 38(1), BSR20171148-BSR20171148 (2018)
Hengwei Zhang et al.
Journal of proteome research, 9(2), 980-989 (2009-12-29)
Oxythiamine (OT), a transketolase inhibitor, is known to inhibit pancreatic cancer cell proliferation. In this study, we investigated the effect of inhibition of the transketolase pathway on signaling pathways in MIA PaCa cancer cells using in-house proteomic techniques. We hypothesized
Functional thiamine deficiency in end-stage renal disease: malnutrition despite ample nutrients
Moradi H and Said HM
Kidney International, 90(2), 252-254 (2016)
商品
Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.
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