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D8375

Sigma-Aldrich

D-2-脱氧葡萄糖

≥98% (GC), crystalline

别名:

2-脱氧葡萄糖, 2-脱氧-D-葡糖

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About This Item

经验公式（希尔记法）:
C6H12O5
CAS号:
154-17-6
分子量:
164.16
Beilstein:
1723331
EC號碼:
205-823-0
MDL號碼:
MFCD00151328
分類程式碼代碼:
12352201
PubChem物質ID:
24894205
NACRES:
NA.25

生物源

synthetic

品質等級

200

化驗

≥98% (GC)

形狀

crystalline

技術

gas chromatography (GC): suitable
inhibition assay: suitable

顏色

white to off-white

mp

146-147 °C (lit.)

溶解度

H2O: 0.250 g/5mL

應用

clinical research
life science and biopharma
metabolomics

儲存溫度

2-8°C

SMILES 字串

OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

InChI

1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

InChI 密鑰

VRYALKFFQXWPIH-PBXRRBTRSA-N

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相关类别

一般說明

2-脱氧-D-葡萄糖是一种不可代谢的葡萄糖类似物，通过靶向己糖激酶（糖酵解的限速步骤）来破坏糖酵解。它被己糖激酶磷酸化为 2-DG-P，在细胞中积累，消耗细胞 ATP。这种方法可以有效地饿死和杀死癌细胞，也可以抑制依赖糖酵解进行复制的病毒细胞。这种多功能分子可应用于癌症、病毒学、代谢组学和生化研究。

應用

2-脱氧-D-葡萄糖（2-DG）用于缺乏葡萄糖补给的研究，以调用和研究反调节反应（CRR）的过程。2-脱氧-D-葡萄糖用于涉及放射和化学敏化以及氧化应激的抗癌策略开发中。

生化／生理作用

2-脱氧-D-葡萄糖（2-脱氧葡萄糖）是一种葡萄糖类似物，可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。 它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。 这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外，2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。

特點和優勢

  • 高纯度化合物适用于各种研究应用

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

其他說明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)
为了全面了解我们针对客户研究提供的各种单糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。

同類產品

产品编号
说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD5901V
WXBD5444V
WXBD5122V
WXBD3525V
WXBD2172V

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