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化驗
≥98%
mp
200-201 °C (lit.)
SMILES 字串
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChI 密鑰
DGABKXLVXPYZII-SIBKNCMHSA-N
基因資訊
human ... NR1H2(7376) , NR1H3(10062)
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一般說明
异去氧胆酸是天然存在的次级胆汁酸。它通过小肠中的肠道菌群产生。在大鼠中,异去氧胆酸在胆汁的肠肝循环过程中由鹅去氧胆酸获得。
應用
异去氧胆酸已被用于:
- 作为液相色谱-质谱(LC-MS)联用法分析大鼠细胞中血清胆汁酸的标准品。
- 作为生长培养基的成分用于研究其作为抗衰老小分子对pex5Δ (Δ) 菌株时序寿命 (CLS) 的影响。
- 作为分析小鼠细胞中胆汁酸组成和总胆汁酸的成分。
也與該產品經常一起購買
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
PloS one, 13(7), e0200908-e0200908 (2018-07-31)
Bile acids are critical contributors to the regulation of whole body glucose homeostasis; however, the mechanisms remain incompletely defined. While the hydrophilic bile acid subtype, ursodeoxycholic acid, has been shown to attenuate hepatic endoplasmic reticulum (ER) stress and thereby improve
Applied and environmental microbiology, 65(7), 3158-3163 (1999-07-02)
From the rat intestinal microflora we isolated a gram-positive rod, termed HDCA-1, that is a member of a not previously described genomic species and that is able to transform the 3alpha,6beta, 7beta-trihydroxy bile acid beta-muricholic acid into hyodeoxycholic acid (3alpha,6alpha-dihydroxy
British journal of pharmacology, 174(8), 672-688 (2017-01-28)
Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here we have evaluated the anti-cholestasis effects of Schisandrol B (SolB), a bioactive compound isolated from
Biochimica et biophysica acta, 1257(2), 189-197 (1995-07-13)
The effects of hyodeoxycholic (HDCA) and alpha-hyocholic acids (alpha-HCA), on cholesterol, bile acid and lipoprotein metabolism, were studied in hamsters. The animals were fed a low cholesterol control diet supplemented with 0.1% HDCA or alpha-HCA for 3 weeks. In both
Biochimica et biophysica acta, 1394(2-3), 199-208 (1998-10-31)
While UDP-glucuronosyltransferases (UGTs) are known to be expressed at high levels in human liver, relatively little is known about extrahepatic expression. In the present study, UGT2B family isoforms involved in the glucuronidation of steroid hormones and bile acids have been
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