推荐产品
product name
Erastin, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5
InChI
1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChI 密鑰
BKQFRNYHFIQEKN-UHFFFAOYSA-N
基因資訊
human ... hRas(3265)
mouse ... hRas(15461)
rat ... hRas(293621)
一般說明
爱拉斯汀是一种细胞可透过性哌嗪基-喹唑啉酮。它与逆向转运系统Xc-相互作用。
應用
爱拉斯汀已用于：
- 肝星状细胞(HSC)中诱导铁死亡的阳性对照
- 诱导铁死亡及人纤维肉瘤HT1080细胞转铁蛋白内化测定
- 诱导肌肉来源细胞系铁死亡
生化／生理作用
Erastin是一种针对携带致癌RAS（即HRAS，KRAS）的肿瘤细胞的选择性抗肿瘤剂。Erastin可通过改变线粒体电压依赖性阴离子通道（VDAC）门控产生铁死亡（一种非凋亡性肿瘤细胞死亡），从而允许阳离子进入线粒体并导致氧化物质释放，进而导致氧化细胞死亡。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
Antonio Bruni et al.
Cell death & disease, 9(6), 595-595 (2018-05-24)
Human islet transplantation has been hampered by donor cell death associated with the islet preparation procedure before transplantation. Regulated necrosis pathways are biochemically and morphologically distinct from apoptosis. Recently, ferroptosis was identified as a non-apoptotic form of iron-dependent regulated necrosis
Ding Wang et al.
Biochemical and biophysical research communications, 480(4), 602-607 (2016-10-30)
Dopamine is a neurotransmitter that has many functions in the nervous and immune systems. Ferroptosis is a non-apoptotic form of regulated cell death that is involved in cancer and neurodegenerative diseases. However, the role of dopamine in ferroptosis remains unidentified.
Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines
Codenotti S, et al.
Journal of Cancer Research and Clinical Oncology, 144(9), 1717-1730 (2018)
Sonam Dolma et al.
Cancer cell, 3(3), 285-296 (2003-04-05)
We used synthetic lethal high-throughput screening to interrogate 23,550 compounds for their ability to kill engineered tumorigenic cells but not their isogenic normal cell counterparts. We identified known and novel compounds with genotype-selective activity, including doxorubicin, daunorubicin, mitoxantrone, camptothecin, sangivamycin
Jiao Wu et al.
Nature, 572(7769), 402-406 (2019-07-26)
Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated in diseases such as ischaemic organ damage and cancer1,2. The enzyme glutathione peroxidase 4 (GPX4) is a central regulator of ferroptosis, and protects cells
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