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Merck

D9533

Sigma-Aldrich

去铁胺 甲磺酸盐

≥92.5% (TLC), powder, iron-chelating agent

别名:

DFX甲磺酸盐, 去铁胺, 去铁胺 甲磺酸盐

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About This Item

经验公式(希尔记法):
C25H48N6O8 · CH4O3S
CAS号:
分子量:
656.79
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.32

product name

去铁胺 甲磺酸盐, powder, ≥92.5% (TLC)

品質等級

化驗

≥92.5% (TLC)

形狀

powder

顏色

white to off-white

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN

InChI

1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChI 密鑰

IDDIJAWJANBQLJ-UHFFFAOYSA-N

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應用

甲磺酸去铁胺用途



  • 可预处理细胞,研究其对细胞活力的影响以及与其他化合物的相互作用()
  • 研究对淀粉样蛋白-β(Aβ)诱导的脂质运载蛋白2(Lcn2)生产的影响。()
  • 诱导细菌培养物的铁饥饿。()

生化/生理作用

一种铁螯合剂,常用于研究细胞增殖和凋亡。 体外体内 实验均显示其对血管平滑肌细胞具有抗增殖作用,并抑制G1期细胞的增殖。 据报道,它也诱导p53。 通过螯合铁诱导HL-60细胞凋亡。 经过1μM去铁胺处理48小时后,DNA明显断裂。 细胞经0.1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。 一些研究表明,它具有抗氧化性能,并保护细胞免受H2O2诱导的损伤。
去铁胺被用作一个缺氧模拟物质去稳定低氧诱导因子1 (HIF-1)。 去铁胺通过抑制以HIF-1为靶点的脯氨酰羟化酶(PHDs)降解来稳定HIF-1。 去铁胺的抑制机制可能是通过Fe2+ 与酶活性所需的PHD活性位点的螯合作用而实现的。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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E Porreca et al.
Arteriosclerosis and thrombosis : a journal of vascular biology, 14(2), 299-304 (1994-02-01)
Vascular smooth muscle cell (VSMC) growth is a primary component of accelerated and spontaneous atherosclerosis. Previous studies have shown that iron may be involved in the control of enzymatic activities that modulate DNA synthesis in human cells. In this study
W G An et al.
Nature, 392(6674), 405-408 (1998-04-16)
Although hypoxia (lack of oxygen in body tissues) is perhaps the most physiological inducer of the wild-type p53 gene, the mechanism of this induction is unknown. Cells may detect low oxygen levels through a haem-containing sensor protein. The hypoxic state
Yuanyuan Kong et al.
Cell death & disease, 10(9), 624-624 (2019-08-20)
Recent findings demonstrate that aberrant downregulation of the iron-exporter protein, ferroportin (FPN1), is associated with poor prognosis and osteoclast differentiation in multiple myeloma (MM). Here, we show that FPN1 was downregulated in MM and that clustered regularly interspaced short palindromic
Xueping Guo et al.
PloS one, 9(4), e94156-e94156 (2014-04-17)
Hyaluronidases are a family of enzymes that degrade hyaluronic acid (hyaluronan, HA) and widely used in many fields. A hyaluronidase producing bacteria strain was screened from the air. 16S ribosomal DNA (16S rDNA) analysis indicated that the strain belonged to
T Sánchez-Elsner et al.
The Journal of biological chemistry, 276(42), 38527-38535 (2001-08-04)
Signaling by transforming growth factor (TGF)-beta family members is mediated by Smad proteins that regulate gene transcription through functional cooperativity and association with other DNA-binding proteins. The hypoxia-inducible factor (HIF)-1 is a transcriptional complex that plays a key role in

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