推荐产品
等級
pharmaceutical primary standard
API 家族
deferoxamine
製造商/商標名
EDQM
應用
pharmaceutical (small molecule)
格式
neat
SMILES 字串
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI 密鑰
IDDIJAWJANBQLJ-UHFFFAOYSA-N
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一般說明
本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持,请访问现行药典网站。
應用
甲磺酸去铁胺EP参考标准品的预期用途是欧洲药典规定的实验室测试。
生化/生理作用
一种铁螯合剂,常用于研究细胞增殖和凋亡。 体外 和 体内 实验均显示其对血管平滑肌细胞具有抗增殖作用,并抑制G1期细胞的增殖。 据报道,它也诱导p53。 通过螯合铁诱导HL-60细胞凋亡。 经过1μM去铁胺处理48小时后,DNA明显断裂。 细胞经0.1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。 一些研究表明,它具有抗氧化性能,并保护细胞免受H2O2诱导的损伤。
包裝
本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录。
其他說明
可能适用相应的销售限制。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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