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Merck
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C9270

Sigma-Aldrich

香豆霉素 A1

别名:

Notomycin A1

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About This Item

经验公式（希尔记法）:
C55H59N5O20
CAS号:
4434-05-3
分子量:
1110.08
Beilstein:
470805
MDL號碼:
MFCD00057312
分類程式碼代碼:
51102829
PubChem物質ID:
329775201
NACRES:
NA.85

形狀

powder

溶解度

DMSO: 50 mg/mL

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

DNA synthesis | interferes
enzyme | inhibits

SMILES 字串

CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc3ccc4C(O)=C(NC(=O)c5c[nH]c(C(=O)NC6=C(O)c7ccc(O[C@@H]8OC(C)(C)[C@H](OC)[C@@H](OC(=O)c9ccc(C)[nH]9)[C@H]8O)c(C)c7OC6=O)c5C)C(=O)Oc4c3C)OC1(C)C

InChI

1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1

InChI 密鑰

WTIJXIZOODAMJT-DHFGXMAYSA-N

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一般說明

Chemical structure: coumarin-glycoside

應用

Coumermycin A1 is an aminocoumarin antibiotic used to study processes such as DNA replication, transcription, and recombination that involve DNA topoisomerase II activity. It has been used to treat Staphylococcus aureus endocarditis in the rat model and to study the effect of coumermycin A1 on the expression of 67 fusions in Salmonella typhimurium. .

生化／生理作用

Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.

其他說明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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S B Jovanovich et al.
Journal of bacteriology, 169(10), 4431-4435 (1987-10-01)
We have estimated the extent to which relaxation of supercoiling by the DNA gyrase inhibitor coumermycin A1 affects gene expression in vivo in Salmonella typhimurium. We isolated a set of Mu d1-8 Lac+ operon fusions to random promoters and measured
Joseph A Burlison et al.
Organic letters, 8(21), 4855-4858 (2006-10-06)
[structure: see text] The coumarin antibiotics are not only potent inhibitors of DNA gyrase but also represent the most effective C-terminal inhibitors of 90 kDa heat shock proteins (Hsp90) reported thus far. In contrast to the N-terminal ATP-binding site, little
Ryan C Chai et al.
Molecular oncology, 11(5), 567-583 (2017-03-18)
Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not
C M Perronne et al.
Antimicrobial agents and chemotherapy, 31(4), 539-543 (1987-04-01)
The efficacy of a 5-day treatment with coumermycin A1 (hereafter referred to as coumermycin) (at three dosage regimens), with ciprofloxacin, or with coumermycin plus ciprofloxacin was tested in experimental aortic valve endocarditis induced in rats by a strain of methicillin-susceptible
Lutz Heide
Methods in enzymology, 459, 437-455 (2009-04-14)
The aminocoumarin antibiotics novobiocin, clorobiocin and coumermycin A(1) are formed by different Streptomyces strains and are potent inhibitors of bacterial gyrase. Their biosynthetic gene clusters have been analyzed in detail by genetic and biochemical investigations. Heterologous expression of these gene
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