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Key Documents

SRP4388

Sigma-Aldrich

SDF-1alpha (CXCL12) from mouse

recombinant, expressed in E. coli, ≥99% (SDS-PAGE), ≥99% (HPLC)

Synonym(s):

CXCL12, PBSF, Pre-B cell growth-stimulating factor, SDF-1, chemokine (C-X-C motif) ligand 12, hIRH

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About This Item

MDL number:
MFCD01867605
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

assay

≥99% (HPLC)
≥99% (SDS-PAGE)

form

lyophilized

potency

50-100 ng/mL

mol wt

~7.9 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

P40224

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Sdf1(20315)

General description

Stromal Cell-Derived Factor-1α (SDF-1α) is a recently discovered protein belonging to the α-chemokine (C-X-C) family of cytokines. Recombinant mouse SDF-1α is a 7.9kDa protein containing 68 amino acids residues.

Biochem/physiol Actions

Stromal Cell-Derived Factor-1α (SDF-1α) is a pleiotropic chemokine. It works as a chemoattractant for T- and B-lymphocytes and inflammatory monocytes. In neural stem cells, SDF-1α is needed for proliferation, survival, migration, intercellular interaction and guidance to neuronal axon. It is responsible for pathogenic inflammation in the central nervous system (CNS). It also controls BMP (bone morphogenic protein)-associated osteogenic differentiation.

Physical form

Lyophilized from 10 mM acetic acid. The protein may appear as a haze or film, which is difficult to see at the bottom of the vial.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitution in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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BMP2 Regulation of CXCL12 Cellular, Temporal, and Spatial Expression is Essential During Fracture Repair.
Myers TJ, et al.
Journal of Bone and Mineral Research, 30, 2014-2027 (2015)
Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system.
Lazarini F, et al.
Glia, 42, 139-148 (2003)
Tünde Kovács et al.
Scientific reports, 9(1), 1300-1300 (2019-02-06)
Recent studies showed that changes to the gut microbiome alters the microbiome-derived metabolome, potentially promoting carcinogenesis in organs that are distal to the gut. In this study, we assessed the relationship between breast cancer and cadaverine biosynthesis. Cadaverine treatment of
Rina Zilkha-Falb et al.
Journal of neuroinflammation, 13, 7-7 (2016-01-10)
Demyelination and axonal degeneration, hallmarks of multiple sclerosis (MS), are associated with the central nervous system (CNS) inflammation facilitated by C-X-C motif chemokine 12 (CXCL12) chemokine. Both in MS and in experimental autoimmune encephalomyelitis (EAE), the deleterious CNS inflammation has
Fan Yang et al.
Cancer research, 79(4), 735-746 (2018-12-26)
Dipeptidyl peptidase (DPP)-4 is a multifunctional glycoprotein involved in various biological and pathologic processes. DPP-4 has been widely recognized as a therapeutic target for type 2 diabetes mellitus but is also implicated in the development of human malignancies. Here, we

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