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Key Documents

SAB3500395

Sigma-Aldrich

Anti-PDL-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

PDL2 Antibody - Anti-PDL-2 antibody produced in rabbit, Pdl2 Antibody, Anti-B7DC, Anti-PD-L2, Anti-Programmed cell death 1 ligand-2, Anti-Programmed death ligand 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 30 kDa

species reactivity

human, rat, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_079515

UniProt accession no.

Q9BQ51

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PDCD1LG2(80380)

General description

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as butyrophilin B7-DC or CD273. It belongs to the immunoglobulin superfamily. The gene encoding PDL-2 is localized on human chromosome 9p24.1.

Immunogen

PDL-2 antibody was raised against a 16 amino acid peptide from near the center of human PDL-2.

Application

Anti-PDL-2 antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

The expression of programmed cell death 1 ligand 2 (PD-L2) or CD antigen 273 (CD273) is up-regulated by interferon-γ (IFNG/IFN-γ) stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with colony-stimulating factor-2 (CSF2) and interleukin-4 (IL-4). PD-L2 is involved in the co-stimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500395.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression of PD-1, PD-L1 and PD-L2 is associated with differentiation status and histological type of endometrial cancer
Zhongfu Mo
Oncology Letters (2016)
Konstantinos Georgiou et al.
Blood, 127(24), 3026-3034 (2016-04-01)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using
PD-L2:PD-1 involvement in T cell proliferation,
cytokine production, and integrin-mediated adhesion
Paul A. Saunders
European Journal of Immunology (2005)
Carlo Sorrentino et al.
Frontiers in immunology, 12, 778329-778329 (2022-01-04)
Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing impact on public health and clinical management. Immunotherapy has shown promise in the treatment of advanced cancers, but needs to be improved for CRC, since only
Expression of Programmed Cell Death 1 Ligand 2 (PD-L2) is a Distinguishing Feature of Primary Mediastinal (Thymic) Large B-cell Lymphoma and Associated with PDCD1LG2 Copy Gain
Min Shi
American Journal of Surgical Pathology (2014)
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