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S1384

Sigma-Aldrich

N-Succinyl-Ala-Ala-Val p-nitroanilide

elastase substrate

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About This Item

Empirical Formula (Hill Notation):
C21H29N5O8
CAS Number:
61043-47-8
Molecular Weight:
479.48
EC Number:
262-569-3
MDL number:
MFCD00038473
UNSPSC Code:
12352204
PubChem Substance ID:
24899476

assay

≥98% (TLC)

form

powder

solubility

1 N NH4OH: 50 mg/mL, clear, yellow

storage temp.

2-8°C

SMILES string

CC(C)C(NC(=O)C(C)NC(=O)C(C)NC(=O)CCC(O)=O)C(=O)Nc1ccc(cc1)N(=O)=O

InChI

1S/C21H29N5O8/c1-11(2)18(21(32)24-14-5-7-15(8-6-14)26(33)34)25-20(31)13(4)23-19(30)12(3)22-16(27)9-10-17(28)29/h5-8,11-13,18H,9-10H2,1-4H3,(H,22,27)(H,23,30)(H,24,32)(H,25,31)(H,28,29)

InChI key

IFAOJWCXOQHSQT-UHFFFAOYSA-N

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

Substrate for human and rat leukocyte elastases

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBS2944V
BCBJ2221V
BCBG9764V
1395470
1397465

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H R Wenzel et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361(9), 1413-1416 (1980-09-01)
A simple synthesis is described for 3-carboxypropionyl-Ala-Ala-Val-4-nitroanilide, a convenient and very specific substrate for human leukocyte elastase (Km = 1.0mM, kcat = 8.7 s-1). The substrate does not undergo appreciable spontaneous hydrolysis. It is not cleaved by trypsin or chymotrypsin
Rami A Al-Horani et al.
Molecules (Basel, Switzerland), 24(11) (2019-06-09)
Pentamidine is bis-oxybenzamidine-based antiprotozoal drug. The parenteral use of pentamidine appears to affect the processes of blood coagulation and/or fibrinolysis resulting in rare but potentially life-threatening blood clot formation. Pentamidine was also found to cause disseminated intravascular coagulation syndrome. To
Stein, R.L.,
Journal of the American Chemical Society, 105, 5111-5111 (1983)
G D Virca et al.
European journal of biochemistry, 144(1), 1-9 (1984-10-01)
Rat is a likely test animal for determining the efficacy of proteinase inhibitor drugs directed toward human leukocyte elastase and cathepsin G. We therefore sought to assess and compare relevant properties of both human and rat leukocyte elastase and cathepsin

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