PZ0148

CP-802079 hydrochloride hydrate

≥98% (HPLC)

• Synonym(s): ({3-(4-Chlorophenyl)-3-[4-(thiazole-carbonyl)-phenoxy]-propyl}-methyl-amino)-acetic acid hydrochloride hydrate, N-[3-(4-Chlorophenyl)-3-[4-(2-thiazolylcarbonyl)phenoxy]propyl]-N-methyl-glycine hydrochloride hydrate
• Empirical Formula (Hill Notation): C₂₂H₂₁ClN₂O₄S · xHCl · yH₂O
• CAS Number: 736175-49-8
• Molecular Weight: 444.93 (anhydrous free base basis)
• MDL number: MFCD18452850
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823733
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: very light brown
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cl.CN(CCC(Oc1ccc(cc1)C(=O)c2nccs2)c3ccc(Cl)cc3)CC(O)=O
• InChI: 1S/C22H21ClN2O4S.ClH.H2O/c1-25(14-20(26)27)12-10-19(15-2-6-17(23)7-3-15)29-18-8-4-16(5-9-18)21(28)22-24-11-13-30-22;;/h2-9,11,13,19H,10,12,14H2,1H3,(H,26,27);1H;1H2
• InChI key: CVQXAUBKPDYXHF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CP-802079 is a potent and selective glycine transporter type 1 (GlyT1) antagonist. Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, they can augment NMDAR currents and NMDAR-mediated functions. CP-802,079 significantly increases the amplitude of the NMDAR currents and LTP.

Features and Benefits

This compound is featured on the Glycine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable