Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

View All Documentation

O6503

Sigma-Aldrich

L-Ornithine monohydrochloride

BioReagent, suitable for cell culture, ≥99%

Synonym(s):

(S)-2,5-Diaminopentanoic acid monohydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
3184-13-2
Molecular Weight:
168.62
Beilstein/REAXYS Number:
3625847
EC Number:
221-678-6
MDL number:
MFCD00064562
UNSPSC Code:
12352209
PubChem Substance ID:
24898036
NACRES:
NA.75

biological source

microbial

product line

BioReagent

assay

≥99%

form

powder

packaging

pkg of 100 g
pkg of 25 g

technique(s)

cell culture | mammalian: suitable

impurities

ammonia and citrulline, essentially free

solubility

H2O: soluble 50 mg/mL, clear, colorless to very faintly yellow

SMILES string

Cl.NCCC[C@H](N)C(O)=O

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1

InChI key

GGTYBZJRPHEQDG-WCCKRBBISA-N

Looking for similar products? Visit Product Comparison Guide

General description

L-Ornithine is the functional metabolite of L-arginine.
L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.

Application

L-Ornithine monohydrochloride has been used:
  • as a supplement in Dulbecco′s modified eagle medium (DMEM) for cell growth assays
  • as a component in the standard medium for primary human hepatocytes (PHH) culture
  • as a creatine synthesis inhibitor

Biochem/physiol Actions

L-ornithine acts as a precursor for polyamines. It may modulate the intake of food as an acute satiety signal in the neonatal chick brain.
L-Ornithine is used as a media supplement to support the biosynthesis of polyamines.

Other Notes

Product of arginine degradation by arginase

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Z N Canellakis et al.
The Yale journal of biology and medicine, 62(5), 481-491 (1989-09-01)
The polyamines and their derivatives are essential for life in eukaryotic and most prokaryotic cells, but their exact role in preserving cell function is not clear. These polyamines provide endogenous cations and thus participate in regulation of the intracellular pH;
Arginase 2 suppresses renal carcinoma progression via biosynthetic cofactor pyridoxal phosphate depletion and increased polyamine toxicity
Ochocki JD, et al.
Cell Metabolism, 27(6), 1263-1280 (2018)
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
Ji L, et al.
Immunity, 51(2), 272-284 (2019)
Arginine
Profiles of Drug Substances, Excipients, and Related Methodology, 27, 1-32 (2001)
L-Ornithine is a potential acute satiety signal in the brain of neonatal chicks
Tran PV, et al.
Physiology & Behavior, 155, 141-148 (2016)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service