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I1877

Sigma-Aldrich

Isocitric Dehydrogenase (NADP) from porcine heart

Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)

Synonym(s):

threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH, IDH

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About This Item

CAS Number:
9028-48-2
Enzyme Commission number:
1.1.1.42 (BRENDA, IUBMB)
EC Number:
232-835-3
MDL number:
MFCD00131420
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

Porcine heart

Quality Level

200

type

Type I

form

solid

specific activity

0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)

storage temp.

−20°C

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Biochem/physiol Actions

Isocitrate dehydrogenase (IDH) plays a major role in the Krebs cycle by catalyzing the oxidative decarboxylation of isocitrate. The oxidative decarboxylation of isocitrate generates α-ketoglutarate and NADPH. NADPH produced is essential for the production of fatty acids and cholesterol. This NADP-dependent molecules serves as homodimers.

Quality

Crude

Unit Definition

One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37°C.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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