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H9903

Sigma-Aldrich

1-(Heptafluorobutyryl)imidazole

BioReagent, suitable for derivatization

Synonym(s):

1-(Perfluorobutyryl)imidazole

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About This Item

Empirical Formula (Hill Notation):
C7H3F7N2O
CAS Number:
32477-35-3
Molecular Weight:
264.10
Beilstein/REAXYS Number:
4488026
EC Number:
251-063-8
MDL number:
MFCD00014503
UNSPSC Code:
12352005
PubChem Substance ID:
24895875
NACRES:
NA.32

product line

BioReagent

bp

158-163 °C (lit.)

suitability

suitable for derivatization

storage temp.

−20°C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)C(=O)n1ccnc1

InChI

1S/C7H3F7N2O/c8-5(9,6(10,11)7(12,13)14)4(17)16-2-1-15-3-16/h1-3H

InChI key

MSYHGYDAVLDKCE-UHFFFAOYSA-N

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General description

1-(Heptafluorobutyryl)imidazole, also known as HFBI, is an acylating derivatization reagent. It is a mild amine-group derivatizing agent. HFBI doesn’t produce acidic by-products in reaction, and the unutilized reagent doesn’t damage the chromatographic process. Post derivatization reaction, the HFB (Heptafluorobutyryl) derivatives are analyzed chromatographically.

Application

1-(Heptafluorobutyryl)imidazole is used as a derivatizing agent for analysing Sulphur mustard metabolites. It is suitable to study dispersive derivatization of degradation products.

Biochem/physiol Actions

Mild amine-group derivatizing reagent; non-acidic by-product prevents decomposition and reduces GC column degradation.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

170.6 °F - closed cup

flash_point_c

77 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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The use of tandem mass spectrometry for the identification and quantitation of tryptolines (tetrahydro-beta-carbolines) in tissue extracts.
J V Johnson et al.
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The N-terminal valine adduct (HETE-Val) in globin is believed to behave as a long-lived biomarker after exposure to sulfur mustard (HD). Development of a highly sensitive method for monitoring HETE-Val, particularly at low HD exposure levels or for retrospective detection
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A Fidder et al.
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