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H4415

Sigma-Aldrich

HC-030031

≥98% (HPLC), powder

Synonym(s):

1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide, 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C18H21N5O3
CAS Number:
349085-38-7
Molecular Weight:
355.39
MDL number:
MFCD02007349
UNSPSC Code:
51111800
PubChem Substance ID:
329815124
NACRES:
NA.25

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

room temp

SMILES string

CC(C)c1ccc(NC(=O)Cn2cnc3N(C)C(=O)N(C)C(=O)c23)cc1

InChI

1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)

InChI key

HEQDZPHDVAOBLN-UHFFFAOYSA-N

Biochem/physiol Actions

HC-030031 is a selective TRPA1 channel blocker, antagonizing formalin-evoked calcium influx and formalin-induced pain. IC50 is 5 μM. TRPA1 antagonism is a promising therapeutic target for chronic inflammatory or neurogenic pain.
HC-030031 is a selective TRPA1 channel blocker. HC-030031 antagonizes formalin-evoked calcium influx. IC50 is 5 μM.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Luana Fischer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 311-322 (2016-12-03)
Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo. In this study we evaluated whether TRPA1, SP, histamine and 5-HT
Yan Xu et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 29(6), 692-700 (2018-11-02)
Transient receptor potential ankyrin 1 (TRPA1) and substance P (SP), both expression in sensory neurons, have important roles in stress-induced duodenal lesions. The possible contribution of TRPA1 and SP to stress-induced duodenal lesions was explored by using the water immersion
Anthony Bosson et al.
Molecular neurodegeneration, 12(1), 53-53 (2017-07-08)
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes
Éva Borbély et al.
Frontiers in pharmacology, 11, 594479-594479 (2021-02-02)
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. Therefore, we
Yu-Wei Wu et al.
Glia, 67(2), 246-262 (2018-12-20)
Astrocytes express a complex repertoire of intracellular Ca2+ transients (events) that represent a major form of signaling within individual cells and in astrocytic syncytium. These events have different spatiotemporal profiles, which are modulated by neuronal activity. Spontaneous Ca2+ events appear
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