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biological source
Streptomyces noursei
Quality Level
assay
≥85% (HPLC)
form
solid
color
white to light brown
solubility
H2O: soluble 200 mg/mL
suitability
suitable for (selection agent for molecular genetic research work)
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
fungi
mycobacteria
mycoplasma
parasites
viruses
yeast
mode of action
protein synthesis | interferes
storage temp.
2-8°C
General description
Chemical structure: peptidyl nucleoside
Application
Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.
Biochem/physiol Actions
Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.
Packaging
10mg, 100mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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