319988

Chloroform

contains ethanol as stabilizer, ACS reagent, ≥99.8%

• Synonym(s): Methylidyne trichloride, Trichloromethane
• Empirical Formula (Hill Notation): CHCl₃
• CAS Number: 67-66-3
• Molecular Weight: 119.38
• Beilstein/REAXYS Number: 1731042
• MDL number: MFCD00000826
• UNSPSC Code: 12191502
• PubChem Substance ID: 329753942
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• vapor density: 4.1 (vs air)
• vapor pressure: 160 mmHg ( 20 °C)
• assay: ≥99.8%
• form: liquid
• contains: ethanol as stabilizer
• impurities: Acetone and aldehyde, passes test; Acid and chloride, passes test; Free chlorine (Cl), passes test; H₂SO₄, passes test
• evapn. residue: ≤0.001%
• color: APHA: ≤10
• refractive index: n20/D 1.445 (lit.)
• bp: 60.5-61.5 °C (lit.)
• mp: −63 °C (lit.)
• density: 1.48 g/mL at 25 °C; 1.492 g/mL at 25 °C (lit.)
• cation traces: Pb: ≤0.05 ppm
• storage temp.: room temp
• SMILES string: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H
• InChI key: HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

General description

Chloroform, a halogenated hydrocarbon, is widely used as a solvent and extractant in various manufacturing and laboratory procedures. It can be produced by the chlorination of methane or lower-chlorinated methanes. Additionally, it is employed in the production of dichlorocarbenes, α-trichloromethyl carbinols, and trichlorolithiocarbenoids.

Application

Chloroform can be used as a solvent in the:

• Enzyme-catalyzed ring-opening polymerization of ω-pentadecalactone to prepare polyesters.
• Pd-catalyzed cross-coupling reaction of acid chlorides with arylboronic acids to synthesize diaryl Ketones.
• Enantio- and diastereoselective nitro-Mannich reaction of α-aryl nitromethanes with amido sulfones to synthesize β-nitroamines.
• Diels-Alder reaction to synthesize spiro-fused dihydropyans. The hydrogen bond (CH-O) formed between chloroform and carbonyl oxygen makes the carbonyl group a stronger heterodienophile, resulting in an increased reaction rate.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372
• pcodes: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• target_organs: Central nervous system, Liver,Kidney
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash