31493

Sodium salicylate

puriss. p.a., reag. Ph. Eur., 99.5-101.0% (calc. to the dried substance)

• Synonym(s): 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate
• Linear Formula: HOC₆H₄COONa
• CAS Number: 54-21-7
• Molecular Weight: 160.10
• Beilstein/REAXYS Number: 3732792
• EC Number: 200-198-0
• MDL number: MFCD00002440
• UNSPSC Code: 12352100
• PubChem Substance ID: 57648580
• NACRES: NA.21

Properties

• agency: USP/NF; reag. Ph. Eur.
• Quality Level: 100
• grade: puriss. p.a.
• assay: 99.5-101.0% (calc. to the dried substance)
• impurities: acidic reac. impurities, complies; sulfite or thiosulfate, complies; ≤0.001% heavy metals (as Pb)
• loss: ≤0.3% loss on drying, 105 °C
• mp: >300 °C (lit.)
• anion traces: chloride (Cl^-): ≤20 mg/kg; sulfate (SO₄^2-): ≤500 mg/kg
• cation traces: Fe: ≤10 mg/kg
• suitability: in accordance for appearance of solution
• SMILES string: [Na+].Oc1ccccc1C([O-])=O
• InChI: 1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
• InChI key: ABBQHOQBGMUPJH-UHFFFAOYSA-M

Description

General description

Sodium salicylate can be prepared from the reaction of salicylic acid and ammonia. It exhibits fluorescence at higher concentrations and effectively absorbs β-particles. Due to these properties, it has been employed as fluor for the radioactivity detection in various gels.

Application

Sodium salicylate may be used as phenolic reagent in salicylate method for the determination of ammonia. It may be employed as a hydrotropic agent to study the release of anticancer drug camptothecin (CPT) from the mixed micelles [composed of Pluronic P105 (P105) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)].

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H319,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 208.9 °F - Pensky-Martens closed cup
• flash_point_c: 98.3 °C - Pensky-Martens closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves