15527

Glycine

meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

• Synonym(s): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein/REAXYS Number: 635782
• EC Number: 200-272-2
• MDL number: MFCD00008131
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 57647473
• NACRES: NA.21

Properties

• Quality Level: 200
• assay: 99-101% (based on anhydrous substance)
• form: crystalline powder
• quality: meets analytical specification of Ph. Eur., BP, USP
• technique(s): IR spectroscopy: suitable
• impurities: hydrolyzable substances, complies; organic volatile impurities, complies (GC); residual solvents, complies; ≤0.001% heavy metals (as Pb); ≤1.0% ninhydrin-positive substances
• ign. residue: ≤0.1% (as SO₄)
• loss: ≤0.2% loss on drying, 105 °C, 2 h
• color: white
• pH: 5.9-6.4 (20 °C, 5%)
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• solubility: H₂O: soluble 25 gm in 100 ml at 25 degrees c; H₂O: soluble 39.1 gm in 100 ml at 50 degrees c; alcohol: soluble 0.06 gm in 100 gm (Absolute); pyridine: soluble 164 parts; alcohol: very slightly soluble; diethyl ether: very slightly soluble
• anion traces: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• suitability: complies for appearance of solution; complies for reaction against H₂SO₄; in accordance for identity (IR)
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• Gene Information: rat ... Grin2a(24409)

Description

Application

Glycine was used for preparing platelets from whole-blood samples and study the stimulation of cytokine expression in leukocytes. It was used for biochemical and tolerance tests.

Biochem/physiol Actions

Glycine has a pivotal role in lowering the plasma lipid levels in diabetic and obese patients by activating the CNS. During brain hypoxia glycine can stabilize the energetics disturbances in brain mitochondria. It also increases the in vitro development of porcine blastocysts when used along with glucose.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)