539636

PKC_θ Pseudosubstrate Inhibitor, Myristoylated

The PKC_θ Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKC_θ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): PKC_θ Pseudosubstrate Inhibitor, Myristoylated, Myr-LHQRRGAIKQAKVHHVKC-NH₂, Protein Kinase C _θ Pseudosubstrate Inhibitor, Myristoylated, Myr-LHQRRGAIKQAKVHHVKC-NH₂, Protein Kinase C_θ Pseudosubstrate Inhibitor, Myristoylated
• Empirical Formula (Hill Notation): C₁₀₅H₁₈₂N₃₅O₂₂S
• Molecular Weight: 2318.85
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: water: 2 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell-permeable, reversible, substrate competitive, myristoylated form of the inhibitor of protein kinase C_θ isozyme pseudosubstrate inhibitor (Cat. No. 539634).

Cell-permeable myristoylated protein kinase Cq pseudosubstrate sequence peptide (Cat. No. 539634). Useful for studies of PKC_θ function in intact cells. Sold on the basis of peptide content.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
protein kinase Cθ

Product competes with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

Myr-Leu-His-Gln-Arg-Arg-Gly-Ala-Ile-Lys-Gln-Ala-Lys-Val-His-His-Val-Lys-Cys-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

Other Notes

Osada, S., et al. 1992. Mol. Cell Biol.12, 3930.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable