126850
α1-PDX, Human, Recombinant, E. coli
Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag.
Synonym(s):
α₁-Antitrypsin Portland
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥80% (SDS-PAGE)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
solubility
water: 2.5 mg/mL
shipped in
wet ice
storage temp.
2-8°C
General description
Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag and a FLAG·Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.
Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). Extracellular application of α1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Furin-dependent processing of protein precursors
Furin-dependent processing of protein precursors
Product does not compete with ATP.
Reversible: no
Target Ki: 600 pM against furin-dependent processing of protein precursors
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from PBS.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 7293.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 7293.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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