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850524P

Avanti

CHEMS

Avanti Research™ - A Croda Brand

Synonym(s):

3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHS

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About This Item

Empirical Formula (Hill Notation):
C31H50O4
CAS Number:
1510-21-0
Molecular Weight:
486.73
UNSPSC Code:
12161902
NACRES:
NA.25

description

cholesteryl hemisuccinate

assay

>99% (TLC)

form

powder

mol wt

486.73 g/mol

packaging

pkg of 1 × 1 g (850524P-1g)
pkg of 1 × 5 g (850524P-5g)

manufacturer/tradename

Avanti Research™ - A Croda Brand

technique(s)

protein quantification: suitable

application(s)

cell analysis

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1

InChI key

WLNARFZDISHUGS-MIXBDBMTSA-N

General description

Cholesteryl hemisuccinate (CHEMS) is an acidic cholesterol ester.

Application

CHEMS is suitable:
  • to prepare multifunctional envelope-type nano device (MEND) by a lipid film hydration method based on electrostatic interactions
  • to as a component in bolavesicle
  • to prepare liposome (LS)
  • for the preparation of anionic liposomes by the lipid thin film hydration and freeze/thaw technique and to encapsulate ovalbumin (OVA) and listeriolysin O (LLO)
  • to prepare liposomal membranes to study its effect on the physical–chemical properties of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) liposomes

Biochem/physiol Actions

CHEMS can help to maintain the stability of dioleoylphosphatidylethanolamine (DOPE). This amphipathic lipid is used in mixtures with dioleoylphosphatidylethanolamine (DOPE) to form ′pH sensitive′ fusogenic vesicles. It can control cell growth.

Packaging

20 mL Clear Glass Screw Cap Vial (850524P-1g)
30 mL Amber Wide Mouth Glass Bottle with Screw Cap (850524P-5g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yongrong Yao et al.
Biomaterials science, 8(1), 256-265 (2019-11-07)
Chemotherapy is a dominant treatment modality for different types and stages of cancer. However, hypoxia is one of the undesirable limitations of chemotherapy, which reduces the therapeutic efficiency in cancer treatment, ultimately leading to failure of the treatment. Herein, an
Effect of cholesteryl hemisuccinate on the interfacial properties of phosphatidylcholine bilayers
Massey JB
Biochimica et Biophysica Acta - Biomembranes, 1415(1), 193-204 (1998)
Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules
Homyak CC, et al.
Biomacromolecules, 19(1), 132-140 (2017)
Preparation and evaluation of multifunctional envelope-type nano device loading siRNA
Yin H, et al.
Artificial Cells, Nanomedicine, and Biotechnology (Print), 44(1), 20-26 (2016)
Bolaamphiphilic vesicles encapsulating iron oxide nanoparticles: New vehicles for magnetically targeted drug delivery
Philosof-Mazor L, et al.
International Journal of Pharmaceutics, 450(1-2), 241-249 (2013)
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