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408719

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~800 by LS, average Mn ~600 by GPC

Synonym(s):

PEI, ethylenediamine branched

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About This Item

Linear Formula:
H(NHCH2CH2)nNH2
CAS Number:
25987-06-8
MDL number:
MFCD00084427
UNSPSC Code:
12162002
NACRES:
NA.23

form

viscous liquid

Quality Level

200

mol wt

average Mn ~600 by GPC
average Mw ~800 by LS

refractive index

n20/D 1.5240

density

1.050 g/mL at 25 °C

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChI key

SFLOAOINZSFFAE-UHFFFAOYSA-N

Related Categories

General description

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Application

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO2 adsorbent. Numerous amino groups present in PEI can react with CO2 due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Features and Benefits

  • Branched PEI has better complexation and buffering capacity.
  • High ion exchange capacity and affinity toward proteins.
  • SignificantDNA transfer efficiency.

Physical form

Branched polymer

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

356.0 °F

flash_point_c

180 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ2767
MKCG7251
MKCG3800
MKCG3796
MKCG3795

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Valentina Dinca et al.
Sensors (Basel, Switzerland), 18(12) (2018-12-07)
Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic
Andrew Jajack et al.
PloS one, 14(1), e0210286-e0210286 (2019-01-17)
Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working
Anna Alhaddad et al.
PloS one, 7(12), e52207-e52207 (2013-01-04)
Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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