Skip to Content
MilliporeSigma
All Photos(2)

Documents

224588

Sigma-Aldrich

5-Chlorouracil

ReagentPlus®, 99%

Synonym(s):

5-Chloro-2,4-dihydroxypyrimidine, 5-Chloropyrimidine-2,4(1H,3H)-dione

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C4H3ClN2O2
CAS Number:
1820-81-1
Molecular Weight:
146.53
Beilstein/REAXYS Number:
127173
EC Number:
217-339-7
MDL number:
MFCD00006019
UNSPSC Code:
12352100
PubChem Substance ID:
24853447
NACRES:
NA.22

product line

ReagentPlus®

assay

99%

form

solid

mp

>300 °C (lit.)

solubility

1 M NH4OH: soluble 50 mg/mL

SMILES string

ClC1=CNC(=O)NC1=O

InChI

1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

ZFTBZKVVGZNMJR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied.

Application

5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H341

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

F Kossoski et al.
The Journal of chemical physics, 140(2), 024317-024317 (2014-01-21)
We report on the shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil, as obtained from fixed-nuclei elastic scattering calculations performed with the Schwinger multichannel method with pseudopotentials. Our results are in good agreement with the available electron transmission spectroscopy data
M K McMillian et al.
Cell biology and toxicology, 18(3), 157-173 (2002-06-27)
A simple resazurin-based cytotoxicity assay is presented for screening of cytotoxicity in hepatocytes and liver cell lines. Human hepatoma (HepG2) cells in 96-well culture plates were exposed to known toxic (cisplatin, 5-fluorouracil, ethionine, flufenamic acid, and diflunisal) and control (transplatin
Anionradicals from 5-halouracil substituted oriented DNA after X-irradiation at low temperatures.
K Voit et al.
Radiation and environmental biophysics, 25(3), 175-181 (1986-01-01)
T Sato et al.
Environmental and molecular mutagenesis, 17(4), 258-263 (1991-01-01)
The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4-nitroquinoline N-oxide (4NQO), N-methyl-N'-nitro-N-nitroso-guanidine (MNNG), or benzo[a]pyrene (B[a]p). The inhibitory effects of L-ascorbic acid, glutathione, vanillin, 5-fluorouracil (5-FU)
S M Morris
Mutation research, 297(1), 39-51 (1993-07-01)
The halogenated pyrimidines were synthesized in the 1950s as potential anti-tumor agents after the discovery that certain tumors preferentially incorporated uracil rather than thymine into the DNA. The fluorinated derivatives are widely recognized today as effective treatment modalities, especially with
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service