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15140

Sigma-Aldrich

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride

≥97.0% (AT)

Synonym(s):

BOP-Cl, Phosphoric acid bis(2-oxooxazolidide) chloride

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About This Item

Empirical Formula (Hill Notation):
C6H8ClN2O5P
CAS Number:
Molecular Weight:
254.56
Beilstein/REAXYS Number:
3654596
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

≥97.0% (AT)

form

solid

mp

191 °C (dec.) (lit.)

SMILES string

ClP(=O)(N1CCOC1=O)N2CCOC2=O

InChI

1S/C6H8ClN2O5P/c7-15(12,8-1-3-13-5(8)10)9-2-4-14-6(9)11/h1-4H2

InChI key

KLDLRDSRCMJKGM-UHFFFAOYSA-N

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Application

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride was used in the preparation of hexadepsipeptide.

Other Notes

Reagent for activating the carboxylic group, synthesis of amides ; Esters ; Peptides

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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S. Danishefsky et al
Tetrahedron Letters, 25, 4203-4203 (1984)
Zhao Yanbin et al.
Biochemical and biophysical research communications, 516(1), 102-111 (2019-06-16)
Here, we firstly examined the proliferation and invasion capacities of different osteosarcoma (OS) cell lines, and analyzed the profiling of the differentially expressed circular RNAs(circRNAs). Then, we identified a novel circRNA(circ_101356/circ_0004846, we named circSAMD4 in the present study) and found
J. Cabre et al.
Synthesis, 413-413 (1984)
Yanjie Xu et al.
Molecules (Basel, Switzerland), 10(1), 259-264 (2007-11-17)
Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
R.D. Tung et al.
Journal of the American Chemical Society, 107, 4342-4342 (1985)

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