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1269447

USP

Fenofibrate

United States Pharmacopeia (USP) Reference Standard

Synonim(y):

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester

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About This Item

Wzór empiryczny (zapis Hilla):
C20H21ClO4
Numer CAS:
49562-28-9
Masa cząsteczkowa:
360.83
Numer MDL:
MFCD00133314
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329749836
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

rodzina API

fenofibrate

producent / nazwa handlowa

USP

Zastosowanie

pharmaceutical (small molecule)

format

neat

ciąg SMILES

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

Klucz InChI

YMTINGFKWWXKFG-UHFFFAOYSA-N

informacje o genach

human ... PPARA(5465)

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Fenofibrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Fenofibrate Capsules
  • Fenofibrate Tablets

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

Sales restrictions may apply.
This page may contain text that has been machine translated.

produkt powiązany

Numer produktu
Opis
Cennik

F0048005

Fenofibrate impurity A, European Pharmacopoeia (EP) Reference Standard

1269607

Fenofibrate Related Compound A, United States Pharmacopeia (USP) Reference Standard

F0048010

Fenofibrate impurity B, European Pharmacopoeia (EP) Reference Standard

1269629

Fenofibrate Related Compound C, United States Pharmacopeia (USP) Reference Standard

1269618

Fenofibrate Related Compound B, United States Pharmacopeia (USP) Reference Standard

F0048035

Fenofibrate impurity G, European Pharmacopoeia (EP) Reference Standard

1133558

Choline Fenofibrate, United States Pharmacopeia (USP) Reference Standard

PHR2864

Fenofibrate Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

Piktogramy

Health hazard
GHS08

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H373

Zwroty wskazujące środki ostrożności

P260 - P314 - P501

Klasyfikacja zagrożeń

STOT RE 2 Oral

Organy docelowe

Liver

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Fenofibric acid analytical standard

Supelco

90568

Fenofibric acid

Bezafibrate ≥98%, solid

Sigma-Aldrich

B7273

Bezafibrate

Pitchai Balakumar et al.
Pharmacological research, 63(1), 8-12 (2010-11-26)
Fenofibrate is a third-generation fibric acid derivative employed clinically as a hypolipidemic agent to lessen the risk caused by atherosclerosis. Dyslipidemia is a condition associated with elevated levels of low-density lipoproteins (LDL), very low-density lipoproteins (VLDL) and triglycerides, and reduced
Itoro E Elijah et al.
Burns : journal of the International Society for Burn Injuries, 38(4), 481-486 (2012-01-10)
Fenofibrate is a peroxisome proliferator activated receptor alpha agonist that contains both pro and anti-inflammatory properties, and has been used in the treatment of dyslipidemia and diabetes for decades. Its receptors are expressed in the liver, skeletal muscle, cardiac, enteric
Pascale Massin et al.
Ophthalmic epidemiology, 21(5), 307-317 (2014-08-19)
Fenofibrate reduced progression of diabetic retinopathy in two large randomized studies. The effect of 135 mg fenofibric acid on diabetic macular edema (DME) was evaluated in subjects with existing DME. In this double-blind, randomized, placebo-controlled study, 110 subjects with DME not
Kate McKeage et al.
Drugs, 71(14), 1917-1946 (2011-09-29)
Fenofibrate is a fibric acid derivative indicated for the treatment of severe hypertriglyceridaemia and mixed dyslipidaemia in patients who have not responded to nonpharmacological therapies. The lipid-modifying effects of fenofibrate are mediated by the activation of peroxisome proliferator-activated receptor-α. Fenofibrate
Samuel Rommelaere et al.
PloS one, 9(8), e104925-e104925 (2014-08-21)
Liver is a major regulator of lipid metabolism and adaptation to fasting, a process involving PPARalpha activation. We recently showed that the Vnn1 gene is a PPARalpha target gene in liver and that release of the Vanin-1 pantetheinase in serum
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