1029501

Amlodipine besylate

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): Amlodipine besylate, 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc
• Wzór empiryczny (zapis Hilla): C₂₀H₂₅ClN₂O₅ · C₆H₅SO₃H
• Numer CAS: 111470-99-6
• Masa cząsteczkowa: 567.05
• Numer MDL: MFCD00887594
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329749008
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: amlodipine
• producent / nazwa handlowa: USP
• Zastosowanie: pharmaceutical (small molecule)
• Format: neat
• temp. przechowywania: 2-8°C
• ciąg SMILES: OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
• InChI: 1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
• Klucz InChI: ZPBWCRDSRKPIDG-UHFFFAOYSA-N
• informacje o genach: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Amlodipine besylate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Amlodipine and Atorvastatin Tablets
• Amlodipine and Benazepril Hydrochloride Capsules
• Amlodipine and Olmesartan Medoxomil Tablets
• Amlodipine and Valsartan Tablets
• Amlodipine Besylate
• Amlodipine Besylate Tablets
• Amlodipine Compounded Oral Suspension

Działania biochem./fizjol.

Amlodipine besylate is an L-type calcium channel blocker.

Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the Ca_V1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P312 - P501
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable