V9505
Monoclonal Anti-Vitamin B12 antibody produced in mouse
clone CD-29, ascites fluid
Synonim(y):
Anti-Cyanocobalamin
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
białko sprzężone
unconjugated
forma przeciwciała
ascites fluid
rodzaj przeciwciała
primary antibodies
klon
CD-29, monoclonal
zawiera
15 mM sodium azide
metody
indirect ELISA: 1:5,000
izotyp
IgG1
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
Opis ogólny
Monoclonal Anti-Vitamin B12 antibody reacts with vitamin B12, as well as with vitamin B12-KLH and vitamin B12-BSA conjugates in human plasma and serum.
Vitamin B12 or cobalamin is a water-soluble vitamin. It is the largest and most complex among all the vitamins. Vitamin B12 is naturally found in animal foods, meat, milk, egg, fish and shellfish.
Zastosowanie
Monoclonal Anti-Vitamin (B12) antibody has been used in enzyme linked immunosorbent assay (ELISA)
Monoclonal Anti-Vitamin B12 antibody produced in mouse has also been used in immunocytochemistry.
Działania biochem./fizjol.
Vitamin B12 serves as a cofactor for methionine synthase and L-methylmalonyl−coenzyme A mutase. It is essential for the maintenance and development of CNS. Vitamin B12 deficiency leads to megaloblastic anemia and neuropathy.
Vitamin B12 regulates genomic stability. While increased levels of vitamin B12 have been associated with hepatic and hematological disorders; cobalamin deficiency has been associated with orthostatic hypotension and depression . The antibody also detects coenzyme B12 and methyl vitamin B12, but does not associate with BSA, folic acid, and 5-methyltetrahyrofolic acid.
Vitamin B12 and folic acid can be used for treating disorders of central nervous system (CNS) development, mood, and cognitive decline, including some dementias.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
M Fenech
Mutation research, 475(1-2), 57-67 (2001-04-11)
Folic acid plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM)
Vitamin B12, folic acid, and the nervous system
Reynolds E
Lancet Neurology, 5(11), 949-960 (2006)
Allan Moore et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 14(2), 67-71 (2004-04-20)
Orthostatic hypotension (OH) and vitamin B12 deficiency are common disorders in older people. Several case series have reported an association between vitamin B12 deficiency and OH. The effect of vitamin B12 replacement on this dysfunction has not been studied. We
A A M Ermens et al.
Clinical biochemistry, 36(8), 585-590 (2003-11-26)
Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a
Alec Coppen et al.
Journal of psychopharmacology (Oxford, England), 19(1), 59-65 (2005-01-27)
We review the findings in major depression of a low plasma and particularly red cell folate, but also of low vitamin B12 status. Both low folate and low vitamin B12 status have been found in studies of depressive patients, and
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