V5255
Anti-Vimentin Antibody
mouse monoclonal, VIM-13.2
Synonim(y):
Anty-F5H288
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Polecane produkty
Nazwa produktu
Monoclonal Anti-Vimentin antibody produced in mouse, clone VIM-13.2, ascites fluid
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
ascites fluid
rodzaj przeciwciała
primary antibodies
klon
VIM-13.2, monoclonal
reaktywność gatunkowa
chicken, rat, human, rabbit, frog, mouse
metody
indirect immunofluorescence: 1:200 using cultured chicken fibroblasts
western blot: 1:500 using human fibroblasts cell extract
izotyp
IgM
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... VIM(7431)
mouse ... Vim(22352)
rat ... Vim(81818)
Opis ogólny
Vimentin is a 53 kD type III intermediate filaments expressed in breast myoepithelial cells, osteocytes, langerhans cells of the skin, schwann cells and astrocytes. Monoclonal anti-vimentin antibody can be used in immunofluorescent labeling of frozen tissue sections to localize vimentin in fibroblasts, endothelial cells, lymphoid tissues and melanocytes. It can also be used in western blotting. Mouse anti-vimentin antibody reacts specifically with vimentin. This product has also shown best reactivity with cultured chicken fibroblasts and can also react with human and mouse cells or tissues.The protein monomers consist of α-helical rod, flanked by head and tail domains. The VIM gene is mapped to human chromosome 10p13.
Immunogen
human foreskin fibroblasts
Zastosowanie
Monoclonal anti-vimentin antibody can be used in the following:
- Immunocytochemical localization of vimentin in normal and pathological tissue of mesenchymal origin.
- It can also be used in immunoblotting
- Immunofluorescence
- Further, anti-vimentin antibody can be used to distinguish tumors and metastatic lesions derived from sarcomas, lymphomas, and melanomas.
Działania biochem./fizjol.
Vimentin has a crucial role in maintaining cell shape and motility. It also provides mechanical stress tolerance for mesenchymal cells. Vimentin induces fibroblast motility and promotes wound healing process. Vimentin filaments form a part of cytoskeleton filament system and therefore, support and secure the cell organelles and also maintain cellular integrity. Vimentin is associated with the process of initiation, progression, metastasis and epithelial-mesenchymal transition of cancer cells, thereby contributing to tumorigenesis. Upregulation of this gene is observed in various cancers including prostate cancer, gastrointestinal tumors, lung cancer, breast cancer, CNS tumors and malignant melanoma.
Inne uwagi
This product can be found as purified product that was produced using cell culture hybridoma product.
SAB4200716 Anti-Vimentin antibody, Mouse monoclonal
clone VIM-13.2, purified from hybridoma cell culture
SAB4200716 Anti-Vimentin antibody, Mouse monoclonal
clone VIM-13.2, purified from hybridoma cell culture
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Nie możesz znaleźć właściwego produktu?
Wypróbuj nasz Narzędzie selektora produktów.
produkt powiązany
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Wybierz jedną z najnowszych wersji:
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene.
Kriajevska M V, et al.
The Journal of Biological Chemistry, 269(31), 19679-19682 (1994)
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Huo Y, et al.
Oncotarget, 7(29), 45876-45876 (2016)
N Takahashi et al.
The Journal of biological chemistry, 269(8), 5913-5917 (1994-02-25)
Retinoylation (retinoic acid acylation) is a posttranslational modification of proteins occurring in many eukaryotic cell lines. The widespread occurrence of retinoylation suggests that it may play a role in many effects of retinoic acid (RA) on cells. The regulatory subunits
Lateral association and elongation of vimentin intermediate filament proteins: a time-resolved light-scattering study.
Lopez C G, et al.
Proceedings of the National Academy of Sciences of the USA, 113(40), 11152-11157 (2016)
A novel role of vimentin filaments; binding and stabilization of collagen mRNAs.
Challa A A and Stefanovic B
Molecular and Cellular Biology (2011)
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej