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V1255
D-Valine
suitable for cell culture, BioReagent
Synonim(y):
(R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid
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About This Item
Wzór liniowy:
(CH3)2CHCH(NH2)CO2H
Numer CAS:
Masa cząsteczkowa:
117.15
Beilstein:
1721135
Numer WE:
Numer MDL:
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
NACRES:
NA.75
Polecane produkty
pochodzenie biologiczne
synthetic (organic)
Poziom jakości
linia produktu
BioReagent
Formularz
powder
metody
cell culture | mammalian: suitable
mp
>295 °C (subl.) (lit.)
Warunki transportu
ambient
temp. przechowywania
room temp
ciąg SMILES
CC(C)[C@@H](N)C(O)=O
InChI
1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
Klucz InChI
KZSNJWFQEVHDMF-SCSAIBSYSA-N
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Opis ogólny
L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.
Zastosowanie
D-Valine has been used as a supplement in:
- Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture
- endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture
- DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture
Działania biochem./fizjol.
D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.
D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
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