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T1568

Sigma-Aldrich

Thrombopoietin human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)

Synonim(y):

MGDF, Megakaryocyte colony-stimulating factor, TPO, c-MPL ligand

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About This Item

Numer CAS:
9014-42-0
Numer MDL:
MFCD01095335
Kod UNSPSC:
12352202
NACRES:
NA.32

pochodzenie biologiczne

human

Poziom jakości

100

rekombinowane

expressed in E. coli

Próba

≥98% (SDS-PAGE and HPLC)

Postać

lyophilized powder

siła działania

≤1.0 ng/mL ED50

masa cząsteczkowa

18.6 kDa

opakowanie

pkg of 5 μg

warunki przechowywania

avoid repeated freeze/thaw cycles

metody

cell culture | mammalian: suitable

zanieczyszczenia

endotoxin, tested

numer dostępu UniProt

P40225

temp. przechowywania

−20°C

informacje o genach

human ... THPO(7066)

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Zastosowanie

TPO stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets

Działania biochem./fizjol.

Thrombopoeitin is a primary regulatory factor for megakaryocytopoiesis and thrombopoiesis. The mature form of TPO is a highly conserved glycoprotein, showing homology among various mammals. It is produced by liver and kidney cells. TPO stimulates growth and maturation of megakaryocytes and megakaryocytic colonies from bone marrow cultures. TPO binds and activates an 68-78 kDa glycoprotein receptor belonging to the GH family of cytokine receptors, a family that includes receptors to growth hormone (GH), erythropoietin (EPO), and prolactin (PRL). Like GH and EPO, TPO may bind to its receptor at two distinct sites, initiating receptor dimerization and activation. Analysis of mRNA indicates also the existence of a novel truncated and potentially soluble form of TPO receptor. The viral oncogene v-mlp of the myeloproliferative leukemia virus (MPLV) contains the gene sequence for the entire cytoplasmic and transmembrane domains and a portion of the extracellular domain of c-mlp (TPO receptor).

Postać fizyczna

Lyophilized from a 0.1 % TFA solution containing 250 μg bovine serum albumin

Komentarz do analizy

The biological activity is measured in a cell proliferation assay using MO7e cells.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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